Opiates induce long-term increases in prodynorphin-derived peptide levels in the guinea-pig myenteric plexus
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چکیده
منابع مشابه
Nerve terminal nicotinic cholinergic receptors on excitatory motoneurons in the myenteric plexus of guinea pig intestine.
Nicotinic acetylcholine receptors (nAChRs) localized to excitatory longitudinal muscle motoneurons were studied in segments of guinea pig ileum maintained in vitro. Longitudinal muscle contractions caused by the nAChRs agonists, dimethylphenylpiperazinium (DMPP), nicotine, and cytisine were measured using isometric strain gauge transducers. In normal Krebs' solution, the nAChR agonists caused c...
متن کاملPresynaptic nicotinic acetylcholine receptors in the myenteric plexus of guinea pig intestine.
Presynaptic nicotinic acetylcholine receptors (nAChRs) were studied in myenteric plexus preparations from guinea pig ileum using intracellular electrophysiological methods. Microapplication of nicotine (1 mM) caused a biphasic depolarization in all AH neurons (n = 30) and in 36 of 49 S neurons. Cytisine (1 mM) caused fast depolarizations in S neurons and no response in AH neurons. Mecamylamine ...
متن کاملPre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.
Actions of nociceptin on electrical and synaptic behavior of morphologically and neurochemically identified neurons in the guinea pig duodenal myenteric plexus were studied with conventional techniques. Nociceptin hyperpolarized the membrane potential in 104 of 121 AH-type and 28 of 51 S-type neurons with an EC(50) of 11.9 +/- 1.2 nM. Increased K(+) conductance accounted for the hyperpolarizing...
متن کاملAnalysis of fast synaptic pathways in myenteric plexus of guinea pig ileum.
Most fast excitatory postsynaptic potentials (fEPSPs) recorded from guinea pig ileum myenteric plexus are mediated by acetylcholine acting at nicotinic receptors and ATP acting at P2X receptors. These studies examine length and polarity of projection of neurons releasing mediators of fEPSPs. Under ketamine-xylazine anesthesia, animals were sham treated or myenteric pathways were interrupted. Af...
متن کاملOpioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.
We have measured the opioid receptor reserve in the guinea pig ileum myenteric plexus by means of the site-directed alkylating agent, beta-chlornaltrexamine. Treatment of the tissue with low (less than 10 nM) concentrations of beta-chlornaltrexamine caused a parallel shift of the log concentration-response curves for both normorphine and dynorphin A-(1-13). Analysis of the resulting curves indi...
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ژورنال
عنوان ژورنال: Naunyn-Schmiedeberg's Archives of Pharmacology
سال: 1986
ISSN: 0028-1298,1432-1912
DOI: 10.1007/bf00500013